The Sovereign Mind™ Protocol
A physician-led framework designed to reduce Alzheimer’s risk and strengthen long-term cognitive resilience.
The Protocol combines evidence-based strategies involving nutrition, sleep, exercise, supplements, metabolic health, social engagement, and environmental protection.
Rather than waiting for memory loss to appear, the goal is to identify risk early and build “cognitive reserve” decades before symptoms develop.
Created by Bradford Frank, MD, MPH, MBA — triple board-certified psychiatrist and author of Prevent Alzheimer’s Dementia in Seven Easy Steps.
The Protocol combines evidence-based strategies involving nutrition, sleep, exercise, supplements, metabolic health, social engagement, and environmental protection.
Rather than waiting for memory loss to appear, the goal is to identify risk early and build “cognitive reserve” decades before symptoms develop.
Created by Bradford Frank, MD, MPH, MBA — triple board-certified psychiatrist and author of Prevent Alzheimer’s Dementia in Seven Easy Steps.
Perimeter Status Report: Assessment 2026
Is your brain secure, or is it currently under siege?
Check the status of your current defenses to determine your Cognitive Sovereignty Rating.
Analyze Your Results:
- 0-1 Secure Perimeters: STATUS: CRITICAL BREACH. Your brain is currently vulnerable to the "Synergistic Siege." Metabolic and environmental toxins are likely accelerating cellular aging. Immediate implementation of the Seven Steps is required.
- 2-3 Secure Perimeters: STATUS: AT RISK. You have basic defenses, but "Invisible Rain" is still entering the system. You are likely experiencing the "Slow Fade" without realizing it.
- 4 Secure Perimeters: STATUS: SOVEREIGN. You have successfully built a fortress. Your focus is now on Fortification (Step 5) to build a lifetime of cognitive reserve.
The Physician-Strategist's Verdict
"Most people fail to realize their perimeter has been breached until the symptoms of memory loss appear. By then, the siege is decades old. This status report isn't just a quiz—it's your wake-up call to deploy the Sovereign Mind™ Protocol before the damage becomes irreversible."
Daily Strategic Updates ($5/mo)
A subscription to your daily "Explainer" emails. "Get the 2026 data before your doctor even reads it."
The Manuals (Coming Soon)
BOOK
Prevent Alzheimer’s Dementia: In Seven Easy Steps.
JOURNAL
The Seven Steps Brain Health Journal.
The Supplement Fortress
Physician-Vetted Tools for Cognitive Defense
In the "Synergistic Siege" of 2026, the supplement market has become a minefield. Many products—even those found in high-end health stores—are compromised by microplastic-laden coatings, heavy metal contamination, and metabolic fillers that trigger the very "slow fade" we are trying to prevent. In this Fortress, I have filtered out the noise to provide you with a high-integrity "Stack" designed to fuel your Protocol.
The Sovereign Mind™ Zero-Tolerance Policy
Before a supplement is included in this Protocol, it must pass my clinical "Perimeter Audit." I reject any product that contains:
1. Industrial Fillers: No magnesium stearate, titanium dioxide, or artificial colors that cause low-grade systemic inflammation.2. Compromised Delivery Systems: No plastic-based enteric coatings or low-quality softgels that contribute to your cumulative microplastic load.3. Unverified Sourcing: Every recommendation must have a transparent "Chain of Custody" and third-party purity testing to ensure the 2026 data matches what is inside the bottle.
Agmatine
"Numerous studies had demonstrated the neuroprotective effect of agmatine in varied types of neurological diseases, including acute attack (stroke and trauma brain injury) and chronic neurodegenerative diseases (Parkinson's disease, Alzheimer's disease). The potential mechanism of agmatine induced neuroprotection includes anti- oxidation, anti-apoptosis, anti- inflammation, brain blood barrier (BBB) protection and brain edema prevention." Source: Xu W, Gao L, Li T, Shao A, Zhang J. Neuroprotective Role of Agmatine in Neurological Diseases. Curr Neuropharmacol. 2018;16(9):1296- 1305. doi: 10.2174/1570159X15666170808120633. PMID: 28786346; PMCID: PMC6251039.
Helps with
Neuroprotective Reduces harmful tau phosphorylation antioxidant Helps prevent dental caries Potentiates the antidepressant effect Anti-inflammatory Antidepressant Protects mitochondrial function and inhibits of apoptosis Anti-diabetic Protects the blood-brain barrier Hepatoprotective (liver)
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Alpha Lipoic Acid
"In medicine, LA has been shown to reduce the symptoms of diabetic polyneuropathy, acute kidney injury, cancers, and some metabolism-related diseases. This study proves that a-lipoic acid (LA) can stabilize the cognitive function of patients with Alzheimer's disease (AD)." Source: Pei X, Hu F, Hu Z, Luo F, Li X, Xing S, Sun L, Long D. Neuroprotective Effect of a-Lipoic Acid against Aẞ25-35-Induced Damage in BV2 Cells. Molecules. 2023 Jan 24;28(3):1168. doi: 10.3390/molecules28031168. PMID: 36770835; PMCID: PMC9919339.
Helps with
Neuroprotective Antioxidant Cholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Anti-inflammatory Fights COVID-19 Anti-cancer Anti-diabetic May improve sperm quality
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Andrographis
"These findings suggested that the antioxidant, anti- inflammatory, anti- cholinesterase potential of ANDRO [Andrographis] contributed to its neuroprotective effect as well as promising therapeutic candidate for the treatment of cognitive impairment and AD [Alzheimer's dementia]-like symptoms."
Inestrosa NC, Tapia-Rojas C, Lindsay CB, Zolezzi JM. Wnt signaling Pathway Dysregulation in the Aging Brain: Lessons From the Octodon degus. Front Cell Dev Biol. 2020 Aug 5;8:734. doi: 10.3389/fcell.2020.00734. PMID: 32850846; PMCID: PMC7419590.
Inestrosa NC, Tapia-Rojas C, Lindsay CB, Zolezzi JM. Wnt signaling Pathway Dysregulation in the Aging Brain: Lessons From the Octodon degus. Front Cell Dev Biol. 2020 Aug 5;8:734. doi: 10.3389/fcell.2020.00734. PMID: 32850846; PMCID: PMC7419590.
Helps with
Neuroprotective Neuroregenerative Cholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Anti-inflammatory Antioxidant Antistress Protects the liver Antibacterial Antiviral Fights COVID-19 Anticancer Antidiabetic
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Apigenin
"The exposure of AD [Alzheimer's disease] flies to apigenin showed a dose dependent significant decrease in the oxidative stress and delay in the loss of climbing ability. Apigenin also inhibits the activity of acetylcholinesterase. The immunostaining and molecular docking studies suggest that apigenin inhibits the formation of Aẞ-42 aggregates. Apigenin is potent in reducing the AD [Alzheimer's dementia] symptoms being mimicked in the transgenic Drosophila model of AD." Source: Siddique YH, Rahul, Ara G, Afzal M, Varshney H, Gaur K, Subhan I, Mantasha I, Shahid M. Beneficial effects of apigenin on the transgenic Drosophila model of Alzheimer's disease. Chem Biol Interact. 2022 Oct 1;366:110120. doi: 10.1016/j.cbi.2022.110120. Epub 2022 Aug 24. PMID: 36027948.
Helps with
Neuroprotective Cholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Antioxidant Anti-inflammatory Anti-cancer May help fight pulmonary fibrosis in post-COVID-19 patients
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Ashwagandha
"The molecular docking studies revealed that the withanolide-A (Ashwagandha) inhibits acetylcholinesterase in the brain, which could be a potential drug to treat Alzheimer's disease."
Source: Bashir A, Nabi M, Tabassum N, Afzal S, Ayoub M. An updated review on phytochemistry and molecular targets of Withania sonifera (L) Dunal (Ashwagandha). Front Pharmacol, 2023 Mar 29;14:1049334.doi: 10.3389/fphar.2023, 1049334, PMID: 37063285; PMCID: PMC10090468.
Source: Bashir A, Nabi M, Tabassum N, Afzal S, Ayoub M. An updated review on phytochemistry and molecular targets of Withania sonifera (L) Dunal (Ashwagandha). Front Pharmacol, 2023 Mar 29;14:1049334.doi: 10.3389/fphar.2023, 1049334, PMID: 37063285; PMCID: PMC10090468.
Neuroprotective Cholinesterase inhibitor thereby increasing acetylcholine (essential neurotransmitter) Antioxidant Anti-inflammatory Fights COVID-19 Decreases cortisol (stress hormone) Boosts thyroid function Anti-cancer Anti-diabetic
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Berberine
"Overall, the study presents berberine as a potential drug against Alzheimer's disease by providing evidence of its effects in improving memory, neurotransmitter levels and reducing ẞ-secretase expression in the Alzheimer's disease model." Source: Ismail H, Khalid D, Waseem D, Ijaz MU, Dilshad E, Haq IU, Bhatti MZ, Anwaar S, Ahmed M, Saleem S. Bioassays guided isolation of berberine from Berberis lycium and its neuroprotective role in aluminium chloride induced rat model of Alzheimer's disease combined with insilico molecular docking. PLoS One. 2023 Nov 1;18(11):e0286349. doi: 10.1371/journal.pone.0286349. PMID: 37910530; PMCID: PMC10619822.
Neuroprotective Cholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Anti-amyloid (by up-regulating circHDAC9) Improves mitochondrial function Anti-cholesterol Antioxidant Anti-osteoporosis Anti-inflammatory Anti-cancer Anti-diabetic; increases insulin sensitivity *Readily crosses the blood-brain barrier
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Carotenoids
"Interestingly, high intake of carotenoid-rich food may play a role in protecting telomeres by oxidative stress reduction. Accordingly, low plasma ß- carotene concentrations have been found in AD (Alzheimer's Disease) subjects when compared with cognitively healthy subjects."
Source: Boccardi V, Arosio B, Cari L, Bastiani P, Scamosci M, Casati M, Ferri E, Bertagnoli L, Ciccone S, Rossi PD, Nocentini G, Mecocci P. Beta-carotene, telomerase activity and Alzheimer's disease in old age subjects. Eur J Nutr. 2020 Feb;59(1):119-126. doi: 10.1007/s00394-019-01892-y. Epub 2019 Jan 16. PMID: 30649596.
Neuroprotective anticholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Antioxidant & anti-inflammatory Helps eye health; cataracts Strongly anticancer *Protects telomeres (associated with longer life) *(B-cryptoxanthin) Slower biologic aging
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
CoQ10
"Coenzyme Q10 (CoQ10) is a lipid antioxidant and electron transporter in the mitochondrial electron transport system. The availability and activity of CoQ10 is crucial for proper mitochondrial function and cellular bioenergetics. Based on the mitochondrial hypothesis of AD (Alzheimer's Dementia) and the hypothesis of oxidative stress, the regulation of the efficiency of the oxidative phosphorylation system by means of CoQ10 can be considered promising in restoring the mitochondrial function impaired in AD, or in preventing the onset of mitochondrial dysfunction and the development of amyloid and tau pathology in AD."
Source: Fišar Z, Hroudova J. CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease. Antioxidants (Basel). 2024 Feb 2;13(2):191. doi: 10.3390/antiox13020191. PMID: 38397789; PMCID: PMC10885987.
Source: Fišar Z, Hroudova J. CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease. Antioxidants (Basel). 2024 Feb 2;13(2):191. doi: 10.3390/antiox13020191. PMID: 38397789; PMCID: PMC10885987.
Neuroprotective Anti-amyloid Antioxidant Cardiprotective anticholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Helps maintain and normalized vital mitochondrial function Note that mitochondrial function is impaired by lipid-lowering agents (statins) *Can inhibit effects of blood thinners
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Cordyceps
"Network pharmacology demonstrated that Cordycepin exerts a therapeutic effect against Alzheimer's disease via multiple targets and signaling pathways and has huge prospects for application in treating neurodegenerative diseases."
Source: Ma X, Zhao Y, Yang T, Gong N, Chen X, Liu G, Xiao J. Integration of network pharmacology and molecular docking to explore the molecular mechanism of Cordycepin in the treatment of Alzheimer's disease. Front Aging Neurosci. 2022 Dec 23;14:1058780. doi: 10.3389/fnagi.2022.1058780. PMID: 36620771; PMCID: PMC9817107.
Source: Ma X, Zhao Y, Yang T, Gong N, Chen X, Liu G, Xiao J. Integration of network pharmacology and molecular docking to explore the molecular mechanism of Cordycepin in the treatment of Alzheimer's disease. Front Aging Neurosci. 2022 Dec 23;14:1058780. doi: 10.3389/fnagi.2022.1058780. PMID: 36620771; PMCID: PMC9817107.
Neuroprotective Cholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Anti-amyloid Antioxidant Anti-inflammatory Anti-cancer Anti-diabetic
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Fisetin
"Collectively, these findingssuggest that fisetin has potential as a treatment agent for Alzheimer's disease and that its effects occur through several mechanisms, including inhibition of oxidative stress,
adjustments to previous cholinergic dysfunction, anti- inflammatory actions, and decreased apoptotic activity."
Source: Wang Y, Wu X,Ren W,Liu Y, Dai X, Wang S, Huo Q, Sun Y. Protective effects of fisetin in an Aß1-42-induced rat model of Alzheimer's disease. Folia Neuropathol. 2023;61(2):196-208. doi: 10.5114/fn.2023.126893. PMID: 37587894.
Source: Wang Y, Wu X,Ren W,Liu Y, Dai X, Wang S, Huo Q, Sun Y. Protective effects of fisetin in an Aß1-42-induced rat model of Alzheimer's disease. Folia Neuropathol. 2023;61(2):196-208. doi: 10.5114/fn.2023.126893. PMID: 37587894.
Neuroprotective Anticholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Antioxidant Anti-inflammatory Helps fight COVID-19 anti-viral Powerful anti-cancer stimulates nerve synaptic formation stimulates neurogenesis in the hippocampus Helps osteoporosis Decreases insulin resistance Decreases fraility *Senolytic (extends lifespan) *Decreases polymerase I
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Ginger
"Several studies have shown the therapeutic potential of ginger and its constituents for the improvement of cognitive deficits thanks to their anti-amyloidogenic potential, cholinesterase inhibition, and neuroprotective properties."
Source: Schepici G, Contestabile V, Valeri A, Mazzon E. Ginger, a Possible Candidate for the Treatment of Dementias? Molecules. 2021 Sep 21;26(18):5700. doi: 10.3390/molecules26185700. PMID: 34577171; PMCID: PMC8470323.
Source: Schepici G, Contestabile V, Valeri A, Mazzon E. Ginger, a Possible Candidate for the Treatment of Dementias? Molecules. 2021 Sep 21;26(18):5700. doi: 10.3390/molecules26185700. PMID: 34577171; PMCID: PMC8470323.
Neuroprotective Anticholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Antioxidant Anti-inflammatory Anti-bacterial Anti-viral Anti-obesity Anti-diabetic Anti-coagulant Anti-emetic Anti-cancer/Anti-angiogenesis (stop new blood vessels from growing in tumors)
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Ginko Biloba
"The included studies demonstrate treatment benefits of Ginkgo biloba extract EGb 761, mainly on cognitive deficits and neuropsychiatric symptoms, in patients with mild NCD (mild neurocognitive disorder). The drug was safe and well tolerated."
Source: Hort J, Duning T, Hoerr R. Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review. Neuropsychiatric Dis Treat. 2023 Mar 23;19:647-660. doi: 10.2147/NDT.S401231. PMID: 36994422; PMCID: PMC10041984.
Neuroprotective Anticholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Antioxidant Anti-inflammatory Beneficial for gut microbiome & helps restore gut permeability to normal Strong anticancer Pulmoprotective (lung) Anti-osteoporosis Retinoprotective (eye retina) Suppresses tardive dyskinesia (TD) Helps with kidney fibrosis Antidepressant *Improves blood-brain barrier permeability (important for curcumin brain penetration) natural human amino acid that decreases with age Neuroprotective Antioxidant Vital for the production of numerous human chemicals Antidiabetic Helps prevent metabolic syndrome Cardioprotective Promotes endothelial (blood vessel) health *Helps promote longevity!
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Grape Seed
"Our laboratory and others have found that polyphenolic preparations rich in proanthocyanidins, such as grape seed extract, are capable of attenuating cognitive deterioration and reducing brain neuropathology in animal models of AD (Alzheimer's dementia)."
Source: Ono K, Zhao D, Wu Q, Simon J, Wang J, Radu A, Pasinetti GM. Pine Bark Polyphenolic Extract Attenuates Amyloid-B and Tau Misfolding in a Model System of Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2020;73(4):1597-1606. doi: 10.3233/JAD-190543. Erratum in: J Alzheimers Dis. 2020;77(1):457. PMID: 31958081; PMCID: PMC8162892.
Source: Ono K, Zhao D, Wu Q, Simon J, Wang J, Radu A, Pasinetti GM. Pine Bark Polyphenolic Extract Attenuates Amyloid-B and Tau Misfolding in a Model System of Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2020;73(4):1597-1606. doi: 10.3233/JAD-190543. Erratum in: J Alzheimers Dis. 2020;77(1):457. PMID: 31958081; PMCID: PMC8162892.
Neuroprotective Antioxidant Anti-inflammatory Boosts immune function Anti-cancer Anti-diabetic Anti-microbial Antihypertensive Improves cardiovascular disease Helps lipid metabolism Helps with peptic ulcers *Senotherapeutic agent (prolongs lifespan)
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Green Tea Extract
"The results of our research show that tea may be used as a rich source of cholinesterase inhibitors which play a significant role in AD (Alzheimer's dementia) treatment."
Source: Baranowska-Wójcik E, Szwajgier D, Winiarska-Mieczan A. Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors. Nutrients. 2020 Mar 6;12(3):709. doi: 10.3390/nu12030709. PMID:32155927; PMCID: PMC7146204.
Source: Baranowska-Wójcik E, Szwajgier D, Winiarska-Mieczan A. Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors. Nutrients. 2020 Mar 6;12(3):709. doi: 10.3390/nu12030709. PMID:32155927; PMCID: PMC7146204.
Neuroprotective Anticholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Antioxidant Anti-inflammatory Helps with COPD Anti-cancer Anti-diabetic Anti-microbial Anti-viral & possibly helps with COVID-19 Anti-hypertensive Improves cardiovascular disease Helps with menopause Mitigates alcohol-induced liver damag Helps with metabolic syndrome *Lowers epigenetic age
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Horny Goat
"The results confirm that ICA (icariin = Horny Goad Weed = Epimedium brevicornu Maxim) can repair neuronal damage, enhance synaptic plasticity, as well as ultimately improve learning and memory impairment through the regulation of the BDNF-TrkB signaling pathway."
Source: Wan M, Sun S, Di X, Zhao M, Lu F, Zhang Z, Li Y. Icariin improves learning and memory function in Aß1-42-induced AD mice through regulation of the BDNF-TrkB signaling pathway. J Ethnopharmacol. 2024 Jan 10;318(Pt B):117029. doi: 10.1016/j.jep.2023.117029. Epub 2023 Aug 12. Erratum in: J Ethnopharmacol. 2024 May 10;325:117906. PMID: 37579923.
Source: Wan M, Sun S, Di X, Zhao M, Lu F, Zhang Z, Li Y. Icariin improves learning and memory function in Aß1-42-induced AD mice through regulation of the BDNF-TrkB signaling pathway. J Ethnopharmacol. 2024 Jan 10;318(Pt B):117029. doi: 10.1016/j.jep.2023.117029. Epub 2023 Aug 12. Erratum in: J Ethnopharmacol. 2024 May 10;325:117906. PMID: 37579923.
Neuroprotective Helps treat nonalcoholic steatohepatitis (NASH) Antioxidant Anti-inflammatory Anti-osteoporosis Anti-cancer Improves gut microbiota Fights atherosclerosis Antiaging thorough autophagia Putative aphrodisiac Antidepressant
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Luteolin
"Among the natural flavonoids, luteolin is of great importance because of its therapeutic role against neuroinflammation."
Source: Ali SM, Nabi F, Furkan M, Hisamuddin M, Malik S, Zakariya SM, Rizvi I, Uversky VN, Khan RH. Tuning the aggregation behavior of human insulin in the presence of luteolin: An in vitro and in silico approach. Int J Biol Macromol. 2023 May 15;237:124219. doi: 10.1016/j.ijbiomac.2023.124219. Epub 2023 Mar 27.PMID: 36990415.
Source: Ali SM, Nabi F, Furkan M, Hisamuddin M, Malik S, Zakariya SM, Rizvi I, Uversky VN, Khan RH. Tuning the aggregation behavior of human insulin in the presence of luteolin: An in vitro and in silico approach. Int J Biol Macromol. 2023 May 15;237:124219. doi: 10.1016/j.ijbiomac.2023.124219. Epub 2023 Mar 27.PMID: 36990415.
Neuroprotective Anticholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Antioxidant Anti-inflammatory Helps fight COVID-19 Anti-viral Anti-cancer Stimulates nerve synaptic formation Stimulates neurogenesis in the hippocampus Improves mitochondrial function
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Magnesium
"Our findings suggest that high magnesium intake alone may improve cognition in older adults, particularly among non- Hispanic Whites and subjects with sufficient levels of serum vitamin D. "
Source: Tao MH, Liu J, Cervantes D. Association between magnesium intake and cognition in US older adults: National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Alzheimers Dement (N Y). 2022 Feb 1;8(1):e12250. doi: 10.1002/trc2.12250. PMID: 35128033; PMCID: PMC8804621.
Source: Tao MH, Liu J, Cervantes D. Association between magnesium intake and cognition in US older adults: National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Alzheimers Dement (N Y). 2022 Feb 1;8(1):e12250. doi: 10.1002/trc2.12250. PMID: 35128033; PMCID: PMC8804621.
Neuroprotective Antioxidant Anti-inflammatory Anti-cancer Anti-diabetic Cardioprotective/antiarrhythmic Hepatoprotective Anti-diabetic Improves bone health Possibly helps migraines May help insomnia May help with leg cramps *Threonate improved anti-Alzheimer's function of atorvastatin in one study **Magnesium L-Threonate (best brain levels of Mg++)
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Melatonin
"Melatonin levels drop dramatically in the frail aged, potentially contributing to neurological failure and dementia. Melatonin supplementation in animal models of Alzheimer's disease (AD) defers Aß accumulation, enhances its clearance from the CNS, and prolongs animal survival. In AD patients, preliminary data show that melatonin use reduces neurobehavioral signs such as sundowning."
Source: Reiter RJ, Sharma R, Cucielo MS, Tan DX, Rosales-Corral S, Gancitano G, de Almeida Chuffa LG. Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm. Cell Mol Life Sci. 2023 Mar 14;80(4):88. doi: 10.1007/s00018-023-04736-5. PMID: 36917314.
Source: Reiter RJ, Sharma R, Cucielo MS, Tan DX, Rosales-Corral S, Gancitano G, de Almeida Chuffa LG. Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm. Cell Mol Life Sci. 2023 Mar 14;80(4):88. doi: 10.1007/s00018-023-04736-5. PMID: 36917314.
Regulates sleep patterns & circadian rhythm Neuroprotective Antioxidant Anti-inflammatory Anti-bacterial Anti-viral Anti-parasitic Anti-radiation Anti-sepsis Hepatoprotective Anti-obesity Immunoregulatory Anti-cancer; breast CA
MSM
"Whereas, MSM treatment improved histopathological insults and ameliorated level of oxidative stress, neuroinflammation and AD (Alzheimer's dementia) markers as well as modulated TREM- 2/DAP-12/Syk pathway."
Source: Abdel-Rafei MK, Thabet NM. Modulatory effect of methylsulfonylmethane against BPA/y- radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway. Life Sci. 2020 Nov 1;260:118410. doi: 10.1016/j.Ifs.2020.118410. Epub 2020 Sep 12. PMID: 32926927.
Source: Abdel-Rafei MK, Thabet NM. Modulatory effect of methylsulfonylmethane against BPA/y- radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway. Life Sci. 2020 Nov 1;260:118410. doi: 10.1016/j.Ifs.2020.118410. Epub 2020 Sep 12. PMID: 32926927.
Neuroprotective Antioxidant Anti-inflammatory Anti-bacterial Anti- sepsis Improves joint health and bone formation Reduces facial signs of aging and protects against photoaging Helps with fatty liver Anti-diabetic Increases HDL ("good cholesterol") Potentially reduces hair loss May protect against alcohol-induced brain injury May help with periodontal disease Anti-cancer
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Multivitamins
"Daily multivitamin supplementation, compared with placebo, improves memory in older adults. Multivitamin supplementation holds promise as a safe and accessible approach to maintaining cognitive health in older age. " Source: Yeung LK, Alschuler DM, Wall M, Luttmann- Gibson H, Copeland T, Hale C, Sloan RP, Sesso HD, Manson JE, Brickman AM. Multivitamin Supplementation Improves Memory in Older Adults: A Randomized Clinical Trial. Am J Clin Nutr. 2023 Jul;118(1):273-282. doi: 10.1016/j.ajcnut.2023.05.011. Epub 2023 May 24. PMID: 37244291; PMCID: PMC10375458.
Neuroprotective Modest anti-cancer properties Age-Related Eye Disease
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NAC
"Several studies have shown that epicatechin-derived polyphenols from tea improve cognitive performance; also, the polyphenol molecule N-acetylcysteine (NAC) promotes neuroprotection."
Source: Andrade V, Cortés N, Pastor G, Gonzalez A, Ramos-Escobar N, Pastene E, Rojo LE, Maccioni RB. N-Acetyl Cysteine and Catechin-Derived Polyphenols: A Path Toward Multi-Target Compounds Against Alzheimer's Disease. J Alzheimers Dis. 2020;75(4):1219-1227. doi: 10.3233/JAD-200067. PMID: 32390631.
Source: Andrade V, Cortés N, Pastor G, Gonzalez A, Ramos-Escobar N, Pastene E, Rojo LE, Maccioni RB. N-Acetyl Cysteine and Catechin-Derived Polyphenols: A Path Toward Multi-Target Compounds Against Alzheimer's Disease. J Alzheimers Dis. 2020;75(4):1219-1227. doi: 10.3233/JAD-200067. PMID: 32390631.
Neuroprotective Antioxidant Anti-biofilm Anti-inflammatory Protects against liver damage (Tylenol, Paracetamol) overdose Helps respiratory diseases (COPD, emphysema, pulmonary fibrosis and hypertension; asthma, silicosis) Protects against air pollution inducted brain damage Mucolytic effects (similar to Mucinex) Helps treat/prevent COVID-19 **Increases OXR1 Promotes longevity
Take with glycine for longevity
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Nicotinamide Riboside
"Oral nicotinamide riboside may represent a promising stratagem to improve cognitive decline during 'normal' ageing, Alzheimer's disease and other diseases."
Source: Braidy N, Liu Y. Can nicotinamide riboside protect against cognitive impairment? Curr Opin Clin Nutr Metab Care. 2020 Nov;23(6):413-420. doi: 10.1097/MCO.0000000000000691. PMID: 32925178.
Source: Braidy N, Liu Y. Can nicotinamide riboside protect against cognitive impairment? Curr Opin Clin Nutr Metab Care. 2020 Nov;23(6):413-420. doi: 10.1097/MCO.0000000000000691. PMID: 32925178.
Neuroprotective Antioxidant Anti-inflammatory Improves gut microbiota Improves mitochondrial function & increases energy Increases NAD+ Improves survival of those with sepsis May improve gut stem cells May help with knee osteoarthritis When combined with resveratrol, protective against wood smoke Anti-diabetic; helps with diabetic neuropathy May improve lifespan
Caution: may increase blood pressure
Caution: may increase blood pressure
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Omega-3 Fish Oil
"Dietary intake or long-term supplementation of omega-3 fatty acids may help reduce risk of AD (Alzheimer's dementia) or cognitive decline."
Source: Wei BZ, Li L, Dong CW, Tan CC; Alzheimer's Disease Neuroimaging Initiative; Xu W. The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers. Am J Clin Nutr. 2023 Jun;117(6):1096-1109. doi: 10.1016/j.ajcnut.2023.04.001. Epub 2023 Apr 5. PMID: 37028557; PMCID: PMC10447496.
Source: Wei BZ, Li L, Dong CW, Tan CC; Alzheimer's Disease Neuroimaging Initiative; Xu W. The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers. Am J Clin Nutr. 2023 Jun;117(6):1096-1109. doi: 10.1016/j.ajcnut.2023.04.001. Epub 2023 Apr 5. PMID: 37028557; PMCID: PMC10447496.
Neuroprotective Antioxidant Anti-inflammatory Anti-cancer Anti-diabetic Cardioprotective Decreases hypertriglyceridemia Helps with arthritis Helps with depression & bipolar disorder Hepatoprotective Helps with hypertension
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Pomegranate
"In conclusion, pomegranate supplementation can be a promising source of protection against Alzheimer's disease."
Source: Ullah A, Khan A, Ahmed S, Irfan HM, Hafiz AA, Jabeen K, Alruwaili M, Alotaibi M, Al Naeem W, Khan A, Al-Harrasi A. A review of pomegranate supplementation: A promising remedial avenue for Alzheimer's disease. Heliyon. 2023 Nov 15;9(11):e22483. Doi: 10.1016/j.heliyon.2023.e22483. PMID: 38074891; PMCID: PMC10700657.
Source: Ullah A, Khan A, Ahmed S, Irfan HM, Hafiz AA, Jabeen K, Alruwaili M, Alotaibi M, Al Naeem W, Khan A, Al-Harrasi A. A review of pomegranate supplementation: A promising remedial avenue for Alzheimer's disease. Heliyon. 2023 Nov 15;9(11):e22483. Doi: 10.1016/j.heliyon.2023.e22483. PMID: 38074891; PMCID: PMC10700657.
Neuroprotective Anti-amyloid Antioxidant Antiviral (possibly helps with COVID-19) Anti-inflammatory Helps with hypertension Cardioprotective Anti-diabetic Anticancer
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Probiotics
"In conclusion, this study presents evidence supporting the benefits of multi-strain probiotics in enhancing BDNF (Brain-derived neurotrophic factor), ameliorating inflammation and oxidative stress in AD [Alzheimer's Dementia] patients."
Source: Hsu YC, Huang YY, Tsai SY, Kuo YW, Lin JH, Ho HH, Chen JF, Hsia KC, Sun Y. Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer's Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study. Nutrients. 2023 Dec 20;16(1):16. doi: 10.3390/nu16010016. PMID: 38201846; PMCID: PMC10780998.
Source: Hsu YC, Huang YY, Tsai SY, Kuo YW, Lin JH, Ho HH, Chen JF, Hsia KC, Sun Y. Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer's Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study. Nutrients. 2023 Dec 20;16(1):16. doi: 10.3390/nu16010016. PMID: 38201846; PMCID: PMC10780998.
Neuroprotective Decreases neuroinflammation Anti-amyloid Anti-oxidant Improves cognition (MMSE score) Anti-diabetic (decreases insulin) Anti-cholesterol Restores digestive balance
Strains shown to be neuroprotective:
- Bifidobacterium longum
- Bifidobacterium infantis
- Bifidobacterium lactis
- Bifidobacterium breve
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lactobacillus plantarum
- Lactobacillus paracasei (and antiaging)
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Vitamin B12
"This study concluded that there is an association between low levels of vitamin B-12 and the risk of AD."
Source: IShrestha L, Shrestha B, Gautam K, Khadka S, Mahara Rawal N. Plasma Vitamin B-12 Levels and Risk of Alzheimer's Disease: A Case-Control Study. Gerontol Geriatr Med. 2022 Feb 7;8:23337214211057715. doi: 10.1177/23337214211057715. PMID: 35155719; PMCID: PMC8832580.
Source: IShrestha L, Shrestha B, Gautam K, Khadka S, Mahara Rawal N. Plasma Vitamin B-12 Levels and Risk of Alzheimer's Disease: A Case-Control Study. Gerontol Geriatr Med. 2022 Feb 7;8:23337214211057715. doi: 10.1177/23337214211057715. PMID: 35155719; PMCID: PMC8832580.
Neuroprotective Cholinesterase inhibitor – thereby increasing acetylcholine (essential neurotransmitter) Anti-amyloid Promotes mitochondrial health Antiviral Anti-CIVOD-19 Decreases homocysteine levels Necessary for many enzymatic functions Red blood cell production *Metformin can result in B12 deficiency
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Vitamin D
In a 14-year study of 269.229 adults aged 55 - 69, "regular users of vitamin D and multivitamins had 17% and 14% lower risk of AD [Alzheimer's dementia] incidence, respectively."
Source: Chen LJ, Sha S, Stocker H, Brenner H, Schottker B. The associations of serum vitamin D status and vitamin D supplements use with all- cause dementia, Alzheimer's disease, and vascular dementia: a UK Biobank based prospective cohort study. Am J Clin Nutr. 2024 Jan 29:S0002-9165(24)00057-1. doi: 10.1016/j.ajcnut.2024.01.020. Epub ahead of print. PMID: 38296029.
Source: Chen LJ, Sha S, Stocker H, Brenner H, Schottker B. The associations of serum vitamin D status and vitamin D supplements use with all- cause dementia, Alzheimer's disease, and vascular dementia: a UK Biobank based prospective cohort study. Am J Clin Nutr. 2024 Jan 29:S0002-9165(24)00057-1. doi: 10.1016/j.ajcnut.2024.01.020. Epub ahead of print. PMID: 38296029.
Neuroprotective Antioxidant Anti-inflammatory helps immune function Anti-cancer Anti-diabetic Promotes healthy mitochondrial function Improves COVID-19 outcomes Helpful in multiple sclerosis Helps diabetic retinopathy Helps Nonalcoholic fatty liver disease (NAFLD) Essential for bone health *Increases telomere length & decreases biologic age *Antiaging
NOTE: can be toxic in high doses; may increase risk of heart disease (get your vitamin D blood level checked)
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.
Vitamin K
"Overall, both VK1 and VK2 are beneficial for protecting the nervous system and maintaining brain homeostasis, thus playing a positive role in the treatment of AD (Alzheimer's Dementia). According to existing studies, the correlation between VK2 and AD is greater than that of VK1."
Source: Xie Y, Li S, Wu D, Wang Y, Chen J,Duan L, Li S, Li Y. Vitamin K: Infection, Inflammation, and Auto-Immunity. J Inflamm Res. 2024 Feb 20;17:1147-1160. doi: 10.2147/JIR.S445806. PMID: 38406326; PMCID: PMC10893789
Source: Xie Y, Li S, Wu D, Wang Y, Chen J,Duan L, Li S, Li Y. Vitamin K: Infection, Inflammation, and Auto-Immunity. J Inflamm Res. 2024 Feb 20;17:1147-1160. doi: 10.2147/JIR.S445806. PMID: 38406326; PMCID: PMC10893789
Neuroprotective Essential for blood coagulation Antioxidant Anti-inflammatory Helps with Asthma Anti-cancer Anti-diabetic Anti-microbial Anti-viral & possibly helps with COVID-19 Supports cardiovascular health Supports bone metabolism Supports gut health Can help treat hyperlipidemia
NOTE: Statins impair vitamin K metabolism and so taking supplemental vitamin K seems logical if you are taking Statins. * No need to take this if already taking Vitamin D + vitamin K (in one pill)
NOTE: Statins impair vitamin K metabolism and so taking supplemental vitamin K seems logical if you are taking Statins. * No need to take this if already taking Vitamin D + vitamin K (in one pill)
As an Amazon Associate, I earn from qualifying purchases. This recommendation is for informational purposes; please consult your medical professional before starting new supplements.